![]() Particularly, drug release was faster in 3D-printed tablets produced with filaments with lower drug content (both by IMP and HME). The drug content and drug release of 3D-printed tablets containing IND were similar to those of the filament results. Filaments produced by HME with a lower drug content released the drug faster than those with a higher drug content. ![]() ![]() IND-loaded PVA filaments produced by IMP had a low drug content and a rapid drug release. Physicochemical investigations revealed no drug–excipient interaction or degradation. The filaments and 3D printed tablets were evaluated for their physicochemical properties, swelling and matrix erosion behaviors, drug content, and drug release. The 3D-printed tablets were fabricated using a fused deposition modeling 3D printer. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl alcohol (PVA), were prepared by hot-melt extrusion (HME) and compared with IND-loaded filaments prepared with an impregnation (IMP) process. The purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets.
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